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The active ingredient is indoxacarb. Indoxacarb is an antiparasitic agent primarily used to kill adult fleas. Activyl works by interfering with the brain and spinal cord of susceptible insects, resulting in death. Activyl is a topical solution that collects lipid layter of the skin and spreads throughout the coat.

It is not absorbed into the body and does not circulate through the blood stream. Activyl contains Brand Names and Other Names This drug is registered for use in animals only. Not recommended for pregnant or lactating cats or dogs. Activyl is fast drying, however spotted areas may appear wet or oily for up to 24 hours.

Overdose is rare.

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Oral ingestion a cat that licks Activyl may cause drooling, licking, vomiting, shaking of the head, and squinting in some pets. For dogs, Activyl comes in the following sizes. It is approved for cats over 2 pounds, puppies over 4 pounds and both puppies and kittesn over 8 weeks of age.

One pipette is applied topically every 30 days. The duration of administration depends on the condition being treated, response to the medication and the development of any adverse effects. Popular Posts.

Indoxacarb (Activyl® Spot-On) for Dogs and Cats

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My vet no longer carries Advantix II and instead recommended Activyl. I would like some personal stories before I use it. I'm in N. Activyl and Activyl Tick Plus - kills fleas, ticks, and probably ants too! It's pretty new and as a general rule I avoid new meds. Why is your vet no longer carrying Advantix a fine medication and why the switch to a new med?

I smell kickbacks from his saleperson.

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Maybe a cruise, or a year's worth of steak dinners, or free meds for the vet for a year to resell at profit. Not kidding BTW. Good friend of mine is a vet. Seriously, I would want to know why and would not rely on any single person's recommendation, be they a vet or a consumer. Was there an issue with Advantix?

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Were they seeing resistant strains? Side effects? Cost differential? Quite frankly "I just decided to stop selling Brand X and am now recommending Brand Y" from my vet would mandate a whole lot of questions and answers from me. I'd be asking these questions of my veterinary service provider, who I PAY, way before I'd be asking them of random anonymous people on teh interwebs.

I have not witnessed any side effects. I used Vectra before, but it seemed to drive her crazy No fleas or ticks, either on the dog! Originally Posted by didee.

I think most flea and tick products are OTC while you need a script for heartworm meds after dogs are tested. Give heartworm preventative to a dog already infected can sometimes be fatal. Also activyl is cheaper than Advantix II.

My Yorkie was placed on Activyl Tick Plus. It has been a week since his first treatment and no signs of fleas. The only issue is that he is scratching a lot. I am waiting a few more days to see if this subsides before calling his Vet. I've been using activyl now for my pets because it was able to be purchased at our local shelter. My only complaint is it seems to work very well for only about 3 weeks so far, not really a full 30 days and unlike advantage, doesn't seem to quite kill off the flea population in the house.

I know that these meds aren't neccessrily to kill off flea pops in carpets and furniture but for whatever reason they always have worked for me in the past to kill fleas on my floors and wherever the cats lay. With activyl this doesn't seem to be the case. We still vacuum fleas up daily, who are very much alive. But its an awesome medication on the animal for the time it works. We applied a dose to our 3 cats on ;uly 12 and its now august 6 and we see healthy, active fleas on the cat again this week.

So we are appx one week short til the next application yet the fleas are back. I am considering going back to advantage to compare the two.This may result in reduced functionality and affect the graphical presentation of this site. However, all content will still be available. Also available, is Activyl Protector Band for Dogs deltamethrin - a long-lasting flea and tick collar that protects your dog for up to 6 months.

Try the monthly topical flea control that uses enzymes inside the flea to activate the full flea-killing power.

activyl dangers

Achieve long lasting, water-resistant flea and tick control that also repels mosquitoes for up to 6 months with this no-mess and easy to apply solution.

Fleas are tiny pests that can create big problems for your pet. Get the facts, learn how to check for fleas and find the best treatment options for your cat or dog. Ticks can be found right in your own backyard. Research ticks in your area, tick-borne diseases, how to help prevent ticks in your home and what to do if you find a tick on your dog. MyPet understands pet parents can be busy people too!

From new additions to long-time family members, MyPet has the tools you need to take care of your favorite furry friends. Keep track of all your pet's appointments and treatments with the MyPet Reminders app. Create personalized profiles for each pet!

Join the pet parenting newsletter that really delivers. Sign up to receive useful pet parent tips delivered right to your inbox. Find more information, facts and treatment options for stopping and preventing fleas and ticks inside and outside your home.

You have JavaScript disabled This may result in reduced functionality and affect the graphical presentation of this site. Learn More. More Tools From MyPet. Reminders Keep track of all your pet's appointments and treatments with the MyPet Reminders app. MyPet Newsletter Join the pet parenting newsletter that really delivers.

Sign Up. Further Reading Find more information, facts and treatment options for stopping and preventing fleas and ticks inside and outside your home. Biology, treatment, and control of flea and tick infestations. Dryden M, Rust M.

activyl dangers

The cat flea: biology, ecology and control. Vet Parasitol. Birmingham, UK. Dryden MW, et al.Activyl is a spot-on topical formulation for pets with the active ingredient indoxacarb, an antiparasitic agent that helps in killing ticks, fleas as well as their eggs and larvae, breaking their life cycle, and preventing reinfestation [1, 2, 4].

Activyl is used for prevention and treatment of parasitic attacks and the management of allergic dermatitis allergic reactions associated with flea and tick bites. A recent study showed that flea infestation in pets could be effectively controlled by a single application of Activyl [5, 6]. Activyl for Dogs. Instead of reaching its bloodstream, indoxacarb works by bioactivation, a mode of action that changes Activyl into a highly insecticidal substance once it comes in contact with the amidase and esterase enzymes in the body of the tick or flea [3, 4].

So, when the susceptible insect comes in contact with the medicine, its brain, and ventral nerve cord stop functioning, eventually killing it [2, 3]. These effects are rare, and even when they occur, they usually disappear within a few hours to days without treatment [8]. However, if the symptoms persist, make sure to consult your vet. Talk to the vet if your dog or puppy has any known allergic reaction to any drugs, or if it is already receiving any medications or supplements [3].

Be sure to follow dosage as instructed by the vet and read the label directions before use. Each ml of the medication contains mg of indoxacarb. You need to get the right size applicator according to how big your dog is. You can reapply after a month, but never use more than one applicator within 30 days [3, 4]. Avoid grooming, stroking, bathing or shampooing your dog for 2 days after the treatment until the medication dries off completely [6]. The fast-acting topical solution starts killing fleas and ticks within 8 hours of applying, remaining effective for 30 days [4].

Because of its quick-drying, waterproof nature, it continues fighting against parasites even after bathing. Moreover, exposure to sunlight does not reduce its efficacy [7]. Activyl is possibly harmful when absorbed through the skin, inhaled, or ingested. Skin or eye contact may cause irritation and allergic reaction while ingestion may be hazardous to the respiratory and central nervous system [9]. In case of accidental exposure, immediately rinse eyes with water or wash your skin with soap and water.

If irritation or symptoms persist, consult a doctor or contact poison control center for advice [9]. Your email address will not be published. All rights reserved.Thursday, November 30, by Rita Winters. Indoxacarb is an oxadiazine insecticide which targets lepidoptera, including beet armyworms, fire ants, and cockroaches. This chemical is produced by DuPont and marketed in the U.

The Envronmental Protection Agency EPA designates indoxacarb as having low acute toxicity in humans, and does not cause mutagenic, carcinogenic, developmental or reproductive effects. However, out of companies state that indoxacarb should be labeled with acute toxicity, irritant, health hazard and environmental toxicity.

Its chemical name is S -methyl 7-chloro-2,5-dihydro [[ methoxycarbonyl [4- trifluoromethoxy phenyl]amino]carbonyl]indeno[1,2-e][1,3,4]oxadiazine-4a 3H -carboxylate.

Other trade names may include Advion, Arilon, and Avent. Laboratory tests show that indoxacarb, through various routes of exposure, causes negative side effects in rats, mice, rabbits and dogs. The side effects include, but are not limited to, nasal and ocular discharge, immobility, lethargy, tremors, spasms, salivation and rapid weight loss. Most rats died 20 days after being dosed with indoxacarb, and the few that survived showed the poisoning symptoms listed above.

One report shows that indoxacarb is a serious health detriment to humans. A year old farmer ingested indoxacarb as a suicidal attempt. The farmer developed peripheral cyanosis and muddy-brown discoloration of blood, a result of methemoglobinemia MetHb. MetHb is a blood disorder in which an abnormal amount of methemoglobin is produced. Together with hemoglobin, methemoglobin is responsible for absorbing oxygen and delivering it to different parts of the body.

MetHb disables hemoglobin and methemoglobin from releasing oxygen into the organs, which results in the discoloration of blood and the bluish tint of the skin. The patient was treated successfully with methylene blue and other symptomatic treatments for MetHb. Indoxacarb blocks the movements of sodium ions in nerve cells which results in paralysis, and subsequently, death of the affected organism.

This chemical targets the central nervous system. Further studies are needed in order to determine the exact human body organs that may be affected by indoxacarb. Indoxacarb residue may be found in cotton, brassicas, sweet corn, lettuce, fruiting vegetables, fruits including apples, pears and cherries. These items are the registered uses for indoxacarb.

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This chemical may be lethal to humans, especially when ingested. Proper precaution must be observed when using or handling indoxacarb. To avoid inhalation, use proper respiratory gear. Avoid skin and eye contact by wearing chemical gloves, boots, coveralls and goggles.

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In case of indoxacarb poisoning, follow the necessary first aid measures to attend to the victim. When chemical dust is inhaled, transfer the victim to an open area with fresh air. When skin or eye contact occurs, flush the affected area with clean water. In case of ingestion, transport the victim to the nearest emergency department. For all cases mentioned, seek medical attention as soon as possible. Please enable JavaScript to view the comments powered by Disqus.

Privacy Terms All content posted on this site is commentary or opinion and is protected under Free Speech. The information on this site is provided for educational and entertainment purposes only.Keep cats away from treated dogs for 24 hours.

If applied or ingested, contact your veterinarian immediately. S -methyl 7 - chloro - 2,5 - dihydro - 2 - [[ methoxycarbonyl [4 - trifluoromethoxy phenyl]amino] - carbonyl]indeno[1,2 - e][1,3,4]oxadiazine - 4a 3H - carboxylate. Step 1. Hold applicator in upright position away from your face and snap tip open by bending it and folding it back on itself.

Step 2. The dog should be standing for easy application. Part the hair and place applicator tip against the skin between shoulder blades.

Activyl for Cats

Step 3. Squeeze applicator firmly applying entire contents directly to skin. Do not allow run off. Do not have contact with treated area until it is completely dry. When application is complete, follow the Container Handling instructions under the Storage and Disposal section below. Have the product container or label with you when calling a poison control center or doctor or going for treatment. You may also contact the Rocky Mountain Poison Center at for emergency medical treatment information.

Causes moderate eye irritation. Harmful if swallowed. Harmful if absorbed through skin. Avoid contact with eyes, skin or clothing.

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Wash thoroughly with soap and water after handling and before eating, drinking, chewing gum, using tobacco or using the toilet. Remove and wash contaminated clothing before reuse.The dilemma of online shopping:. High priced items are always on the top but their big marketing bucks will be your cost.

The cheapest ones are buried under the pile as our profit margins can't cover the cost. You've found us the hard way, don't let the luck slip away, order your Pet Meds right away! Activyl works by using a method called bioactivation, a method in which the active ingredient, indoxacarb is fully activated by using the flea's own enzymes. Activyl can be used for both dogs and cats, and kills not only adult fleas, but also flea eggs and larvae too; thereby, breaking the flea's lifecycle.

Benefits: New technology for flea control Kills fleas, flea eggs and larvae Breaks flea's lifecycle Quick-drying and fragrance free Waterproof even after bathing Activyl works to break the flea's lifecycle by killing not only adult fleas, but also flea eggs and larvae, which reduces the chances of your pet becoming reinfested.

Activyl is spread through your pet's skin and coat. When a flea lands on your pet, it takes up the active ingredient of Activyl and causes the enzymes in the flea to change. Activyl then reaches its full active form and the flea becomes paralyzed and unable to feed. This process is called bioactivation -- the newest technology in flea control.

In addition, Activyl is waterproof, quick-drying, and fragrance free. Cautions: Do not use Activyl for dogs on cats, or allow your cat to lick or groom a dog treated with Activyl. Do not use on cats or kittens under 2 lbs, or dogs or puppies under 4 lbs, and no kittens or puppies under 8 weeks of age. Certain medications may interact with pesticides.

If signs of sensitivity occur, contact your veterinarian immediately. Brand Name: Activyl. Activyl is a monthly spot-on flea treatment that works like no other flea product on the market.

activyl dangers

Activyl works by a method called bioactivation. This method uses the flea's own enzymes to change Activyl into its fully active form. It kills not only adult fleas, but it also kills eggs and larvae too; thereby, breaking the flea's lifecycle. For Larger Dogs: Start applying the contents between the shoulder blades working your way down to the tail while applying Activyl in spots along the way.

Make sure you thoroughly part the hair on each spot so the applicator touches the skin and not just the fur. What are the side effects of Activyl: Individual sensitivities while rare, may occur after using any pesticide product. In cats, accidental ingestion may cause intermittent salivation, licking of the face, shaking of the head, and squinting.

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